Jan M Keppel Hesselink Selected Research

Phenytoin (Dilantin)

1/2022	No Detectable Phenytoin Plasma Levels After Topical Phenytoin Cream Application in Chronic Pain: Inferences for Mechanisms of Action.
1/2020	Usefulness of a Double-Blind Placebo-Controlled Response Test to Demonstrate Rapid Onset Analgesia with Phenytoin 10% Cream in Polyneuropathy.
1/2019	Ethical justification of single-blind and double-blind placebo-controlled response tests in neuropathic pain and N-of-1 treatment paradigm in clinical settings.
11/2018	Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients.
5/2018	Phenytoin Cream for the Treatment for Neuropathic Pain: Case Series.
1/2018	Phenytoin repositioned in wound healing: clinical experience spanning 60 years.
8/2017	Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action.
6/2017	Phenytoin: neuroprotection or neurotoxicity?
1/2017	Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment.
1/2017	Topical phenytoin for the treatment of neuropathic pain.

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Jan M Keppel Hesselink Research Topics

Disease

15	Neuralgia (Stump Neuralgia) 01/2020 - 01/2011
13	Pain (Aches) 01/2020 - 01/2011
3	Epilepsy (Aura) 01/2018 - 01/2017
2	Polyneuropathies (Polyneuropathy) 01/2020 - 06/2017
2	Cancer Pain 01/2020 - 01/2017
2	Trigeminal Neuralgia (Tic Douloureux) 01/2017 - 01/2017
1	Chronic Pain 01/2022
1	Colic (Abdominal Cramps) 01/2020
1	Burns 01/2020
1	Migraine Disorders (Migraine) 01/2020
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2018
1	Inflammation (Inflammations) 12/2017
1	Breast Neoplasms (Breast Cancer) 08/2017
1	Optic Neuritis (Retrobulbar Neuritis) 08/2017
1	Atrophy 06/2017
1	Demyelinating Diseases (Demyelinating Disease) 06/2017
1	Neuritis (Polyneuritis) 06/2017
1	Hypesthesia (Numbness) 01/2017
1	Stroke (Strokes) 01/2017
1	Neuroinflammatory Diseases 01/2015
1	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2015
1	Carpal Tunnel Syndrome 01/2015
1	Glaucoma 01/2015
1	Nerve Compression Syndromes (Nerve Entrapment) 01/2015
1	Vulvodynia 08/2014
1	Acromegaly 10/2013
1	Complex Regional Pain Syndromes 01/2013
1	Multiple Sclerosis 01/2012
1	Pelvic Pain 12/2011

Drug/Important Bio-Agent (IBA)

12	Analgesics (Analgesic Drugs)IBA 01/2022 - 01/2011
11	Phenytoin (Dilantin)FDA LinkGeneric 01/2022 - 01/2017
5	palmidrolIBA 01/2015 - 12/2011
4	Baclofen FDA LinkGeneric 01/2019 - 10/2013
3	Amitriptyline (Elavil)FDA LinkGeneric 01/2019 - 01/2011
3	Ketamine FDA LinkGeneric 01/2019 - 01/2011
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2017
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2017 - 01/2012
1	Cholecystokinin B ReceptorIBA 01/2020
1	AutacoidsIBA 12/2017
1	LipidsIBA 12/2017
1	Voltage-Gated Sodium ChannelsIBA 06/2017
1	EMA400IBA 01/2017
1	PD 123319IBA 01/2017
1	SPD 502IBA 01/2017
1	Carbamazepine (Tegretol)FDA LinkGeneric 01/2017
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2017
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2015
1	Diclofenac (SR 38)FDA LinkGeneric 01/2015
1	Retinaldehyde (Retinal)IBA 01/2015
1	Opioid Analgesics (Opioids)IBA 01/2015
1	Pregabalin (Lyrica)FDA Link 01/2015
1	4-O-carboxymethylascochlorinIBA 01/2015
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2012
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2011

Therapy/Procedure

3	Analgesia 01/2020 - 01/2017
2	Therapeutics 05/2018 - 06/2017
1	Precision Medicine 11/2018
1	Nutritional Support (Artificial Feeding) 01/2015